2. Signaling Pathways
  3. Cytoskeleton
  4. Arp2/3 Complex

Arp2/3 Complex

Actin-related protein 2/3 complex

Arp2/3 Complex

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The Arp2/3 complex is originally identified in Acanthamoeba and consists of seven proteins (actin-related proteins; Arp2 and Arp3, and Arp2/3 complex subunits; ARPC1-5) that are conserved in all eukaryotes, with the exception of some algae, microsporidia and protists. The complex plays an essential role in a wide variety of cellular processes including lamellipodia-mediated cell migration, endocytosis and phagocytosis, by virtue of its ability to generate branched actin filament networks.

Activation of Arp2/3 requires interaction with actin nucleation-promoting factors (NPFs). Regulation of Arp2/3 activity is achieved by endogenous inhibitory proteins through direct binding to Arp2/3 and competition with NPFs or by binding to Arp2/3-induced actin filaments and disassembly of branched actin networks. Arp2/3 inhibition has recently garnered more attention as it has been associated with attenuation of cancer progression, neurotoxic effects during drug abuse, and pathogen invasion of host cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2463
    Fequesetide
    		99.36%
    Fequesetide, a peptide segment, is the active site within the protein thymosin β4 responsible for actin binding, cell migration and wound healing.
    Fequesetide
  • HY-P2031
    Phallacidin
    Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin.
    Phallacidin
  • HY-N6701
    Dihydrocytochalasin B
    		≥99.0%
    Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings.
    Dihydrocytochalasin B
  • HY-124689
    TR-100
    		Inhibitor ≥99.0%
    TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion.
    TR-100
  • HY-132584
    Casimersen
    Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD).
    Casimersen
  • HY-147253A
    Brogidirsen sodium
    		Activator
    Brogidirsen sodium exerts the stimulatory function of synthesis of functional dystrophin.
    Brogidirsen sodium
  • HY-126989
    19-O-Acetylchaetoglobosin A
    		Inhibitor
    19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells.
    19-O-Acetylchaetoglobosin A
  • HY-NP136
    Myelin basic protein (human)
    		Modulator
    Myelin basic protein human, the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin basic protein human mediates interactions with actin and tubulin and effect of post-translational modifications.
    Myelin basic protein (human)
  • HY-123312
    CK-548
    		Inhibitor
    CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection.
    CK-548
  • HY-P2045
    RA-VII
    RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma.
    RA-VII
  • HY-P1045A
    187-1, N-WASP inhibitor TFA
    		Inhibitor
    187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.
    187-1, N-WASP inhibitor TFA
  • HY-127042
    6,7-Epoxy-latrunculin A
    		Inhibitor
    6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects.
    6,7-Epoxy-latrunculin A
  • HY-164677
    PLH1215
    		Inhibitor
    PLH1215 is a compound used to regulate, limit, or inhibit the expression of AVIL (advillin), which can be utilized in cancer research.
    PLH1215
Cat. No. Product Name / Synonyms Application Reactivity